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Invitrogen™ Phospho-PABPN1 (Ser150) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5105091

Catalog No. PIPA5105091


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Description

Description

Antibody detects endogenous levels of PABP2 only when phosphorylated at Ser150.

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-PABPN1 (Ser150)
Polyclonal
Unconjugated
PABPN1
mPABII; Nuclear poly(A)-binding protein 1; OPMD; PAB2; PABII; PABP2; PABP-2; Pabp3; PABPN1; poly(A) binding protein 2; poly(A) binding protein II; poly(A) binding protein nuclear 1; poly(A) binding protein, nuclear 1; poly(A)-binding protein 2; poly(A)-binding protein II; polyA binding protein II; polyadenylate-binding nuclear protein 1; Polyadenylate-binding protein 2
Rabbit
Sequential Chromatography
RUO
116697, 282298, 54196, 8106
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q28165, Q86U42, Q8CCS6
PABPN1
A synthesized peptide derived from human PABPN1(Accession Q86U42), corresponding to amino acid residues around phosphorylated Ser150.
100 μL
Primary
Human, Mouse, Rat, Bovine
Antibody
IgG
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