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Invitrogen™ Phospho-PAK1/PAK2 (Thr423, Thr402) Polyclonal Antibody
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Catalog No. PIPA5105202
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PIPA5105202 100 μL
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Catalog No. PIPA5105202 Supplier Invitrogen™ Supplier No. PA5105202
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of PAK1 /PAK2 only when phosphorylated at Thr423.

Three isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65 and gammaPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiae kinase Ste 20, involved in pheromone signaling. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on gammaPAK, including Ser 19, Ser 141 and Thr 402, and phosphorylation of Ser 141 and Thr 402 is correlated with gammaPAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PAK1/PAK2 (Thr423, Thr402)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Pak1
Gene Accession No. O88643, P35465, Q13153, Q13177, Q64303, Q8CIN4
Gene Alias 5330420P17Rik; A130002K10Rik; activated protein kinase alpha; AI836325; Alpha-PAK; AW045634; Beta-PAK; CDC42/RAC effector kinase PAK-A; C-t-PAK2; D16Ertd269e; gamma pak; gamma-PAK; mKIAA4182; Oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 1; p21 (CDKN1A)-activated kinase 2; p21 (RAC1) activated kinase 1; p21 (RAC1) activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 2; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21-activated kinase 1; p21-activated kinase 2; p27; p34; p58; p65-PAK; p68-PAK; PAK alpha; PAK beta; PAK gamma; PAK1; PAK-1; Pak2; PAK-2; PAK-2p27; PAK-2p34; PAK3; PAK-3; PAK65; Paka; PAKalpha; PAKgamma; Protein kinase MUK2; S6/H4 kinase; Serine/threonine-protein kinase PAK 1; serine/threonine-protein kinase PAK 2; STE20 homolog, yeast
Gene Symbols Pak1, PAK2
Host Species Rabbit
Immunogen A synthesized peptide derived from human PAK1(Accession Q13153), corresponding to amino acid residues around phosphorylated Thr423.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18479, 224105, 29431, 29432, 5058, 5062
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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