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Invitrogen™ Phospho-PAK6 (Ser165) Polyclonal Antibody
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Catalog No. PIPA5106021
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PIPA5106021 100 μL
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Catalog No. PIPA5106021 Supplier Invitrogen™ Supplier No. PA5106021
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of PAK6 only when phosphorylated at Ser165.

PAK6 is a serine/threonine kinase expressed in the testis and prostate. It associates with both the estrogen and androgen receptors. The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. Later experiments have shown it to be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PAK6 (Ser165)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Pak6
Gene Accession No. Q3ULB5, Q9NQU5
Gene Alias 4732456M09; p21 (CDKN1A)-activated kinase 6; p21 (RAC1) activated kinase 6; p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated kinase 6; PAK5; PAK-5; PAK6; PAK-6; Serine/threonine-protein kinase PAK 6
Gene Symbols Pak6
Host Species Rabbit
Immunogen A synthesized peptide derived from human PAK6(Accession Q9NQU5), corresponding to amino acid residues around phosphorylated Ser165.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 214230, 56924
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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