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Invitrogen™ Phospho-PDCD4 (Ser457) Polyclonal Antibody
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Catalog No. PIPA5105016
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PIPA5105016 100 μL
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Catalog No. PIPA5105016 Supplier Invitrogen™ Supplier No. PA5105016
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of PDCD4 only when phosphorylated at Serine 457.

Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. During this process, the expression patterns of numerous genes are radically altered. One such gene is the programmed cell death protein 4 (PDCD4), whose expression was found to be upregulated in all cell lines following the onset of apoptosis. PDCD4 encodes a tumor suppressor protein whose expression is lost in carcinomas of breast, colon, lung and prostate. It can bind to and inhibit the helicase activity of the eukaryotic translation initiation factor 4A and inhibit the transactivation and transformation mediated by the transcription factor AP-1. The kinase Akt regulates PDCD4 by phosphorylation, decreasing the ability of PDCD4 to interfere with the transactivation of AP-1-responsive promoter by c-Jun. There are two known isoforms of PDCD4.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PDCD4 (Ser457)
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PDCD4
Gene Accession No. Q53EL6, Q61823, Q9JID1
Gene Alias D19Ucla1; death up-regulated gene protein; death-upregulated; Dug; H731; Ma3; MGC33046; MGC33047; Neoplastic transformation inhibitor protein; nuclear antigen H731; Nuclear antigen H731-like; Pdcd4; programmed cell death 4; programmed cell death 4 (neoplastic transformation inhibitor); programmed cell death protein 4; Protein 197/15a; protein MA-3; RP11-348N5.4; Tis; topoisomerase-inhibitor suppressed protein
Gene Symbols PDCD4
Host Species Rabbit
Immunogen A synthesized peptide derived from human PDCD4(Accession Q53EL6), corresponding to amino acid residues around phosphorylated Ser457.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18569, 27250, 64031
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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