Invitrogen™ Phospho-PDE6 gamma (Thr22) Polyclonal Antibody

Catalog No.	Quantity
PIPA5106023	100 μL

Catalog No. PIPA5106023 Supplier Invitrogen™ Supplier No. PA5106023

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of PDE6G only when phosphorylated at Thr22.

The second messengers cAMP and cGMP are key regulatory molecules that are involved in a wide variety of signal transduction pathways. Levels of cAMP and cGMP are regulated by their rate of synthesis by nucleotide cyclases and by their rate of hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). PDEs form a superfamily of enzymes that catalyze the conversion of 3-prime, 5-prime-cyclic nucleotides to the corresponding nucleoside 5-prime-monophosphates. PDE6 is the effector enzyme in the G protein-mediated signal transduction cascade in the visual system. There are five different subunits consisting of rod and cone specific catalytic subunits: alpha' (Cone), alpha (Rod), and beta (Rod), the inhibitory subunit gamma, and subunit delta of unknown function (which likely interacts with many other proteins besides the PDE6 family). The catalytic core of the PDE6 system is comprised of alpha'/alpha' homodimers in the cone and alpha/beta heterodimers in the rod. The C-terminus of both the catalytic and inhibitory subunits is modified by methylation, myristyolation and prenylation which have been shown to be critical for proper complex assembly and membrane association.

Specifications

• Antigen: Phospho-PDE6 gamma (Thr22)
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: PDE6G
• Gene Accession No.: P09174, P18545
• Gene Alias: GMP-PDE gamma; p3AT; PDE6G; PDEG; phosphodiesterase 6G; phosphodiesterase 6G, cGMP-specific, rod, gamma; phosphodiesterase, cyclic GMP (rod receptor), gamma polypeptide; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; rod cG-PDE G; RP57; unnamed protein product
• Gene Symbols: PDE6G
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human PDE6G(Accession P18545), corresponding to amino acid residues around phosphorylated Thr22.
• Purification Method: Sequential chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18588, 5148, 688297
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

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