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Invitrogen™ Phospho-PKD1/2/3/PKC mu (Ser738, Ser742) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA537822
Description
A suggested positive control for Western blot is A549 cells.
Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane.
Specifications
Phospho-PKD1/2/3/PKC mu (Ser738, Ser742) | |
Polyclonal | |
Unconjugated | |
PRKD3 | |
4930557O20Rik; 5730497N19Rik; AI325941; EPK2; HSPC187; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-nu; Pkcm; PKC-MU; Pkcnu; PKC-NU; PKD; PKD1; PKD2; PKD3; Prkcm; Prkcn; Prkd1; PRKD2; Prkd3; Protein kinase C mu type; protein kinase C nu type; protein kinase C, mu; protein kinase C, nu; protein kinase D; protein kinase D1; protein kinase D2; protein kinase D3; protein kinase EPK2; RGD1308054; Serine/threonine-protein kinase D1; serine/threonine-protein kinase D2; Serine/threonine-protein kinase D3 | |
Rabbit | |
Affinity Chromatography | |
RUO | |
101540, 18760, 23683, 25865, 292658, 313834, 5587, 75292, 85421 | |
-20°C | |
Liquid |
Western Blot | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
O94806, Q15139, Q5XIS9, Q62101, Q8BZ03, Q8K1Y2, Q9BZL6, Q9WTQ1 | |
PRKD1, PRKD2, PRKD3 | |
Peptide sequence around phosphorylation site of Serine738/Serine 742 (E-K-S(p)-F-R-R-S(p)-V-V) derived from Human PKD1/2/3/PKC mu. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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