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Invitrogen™ Phospho-PDPK1 (Ser241) Monoclonal Antibody (K.424.2)
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Catalog No. PIMA514780
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100 μL
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Catalog No. Quantity
PIMA514780 100 μL
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Catalog No. PIMA514780 Supplier Invitrogen™ Supplier No. MA514780
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Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody.

PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PDPK1 (Ser241)
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone K.424.2
Concentration 62 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
Gene Pdpk1
Gene Accession No. O15530, O55173, Q9Z2A0
Gene Alias 3-phosphoinositide dependent protein kinase 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; HGNC:8809; hPDK1; isoenzyme 1; kinase isoenzyme 1; lipoamide; mPDK1; OTTHUMP00000174525; OTTHUMP00000205076; PDK1; PDPK1; PDPK2; PDPK2P; Pkb kinase; PkB kinase like gene 1; PkB-like 1; PRO0461; Protein kinase B kinase
Gene Symbols Pdpk1
Host Species Rabbit
Immunogen Synthetic phosphopeptide corresponding to residues around pSer241 of human PDK1.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18607, 5170, 81745
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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