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Invitrogen™ Phospho-PDPK1 (Ser241) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5121278

Catalog No. PIPA5121278


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Description

Description

Positive test controls include: NIH/3T3. The target is usually found in the following locations: Cell junction, Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein, focal adhesion. Immunogen sequence: ANSFV.

PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-PDPK1 (Ser241)
Polyclonal
Unconjugated
Pdpk1
3-phosphoinositide dependent protein kinase 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; HGNC:8809; hPDK1; isoenzyme 1; kinase isoenzyme 1; lipoamide; mPDK1; OTTHUMP00000174525; OTTHUMP00000205076; PDK1; PDPK1; PDPK2; PDPK2P; Pkb kinase; PkB kinase like gene 1; PkB-like 1; PRO0461; Protein kinase B kinase
Rabbit
Affinity Chromatography
RUO
18607, 5170, 81745
-20°C, Avoid Freeze/Thaw Cycles
Liquid
ELISA, Western Blot, Immunocytochemistry
0.57 mg/mL
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
O15530, O55173, Q9Z2A0
Pdpk1
A synthetic phosphorylated peptide around S241 of human PDK1/PDPK1 (NP_002604.1).
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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