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Invitrogen™ Phospho-PDPK1 (Ser241) Recombinant Rabbit Monoclonal Antibody (3P2U4)
Rabbit Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA551528
Description
Immunogen sequence: ANSFV.
PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
Specifications
Phospho-PDPK1 (Ser241) | |
Recombinant Monoclonal | |
0.22 mg/mL | |
PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3 | |
O15530 | |
Pdpk1 | |
A synthetic phosphorylated peptide around S241 of human Phospho-PDK1/PDPK1-S241 (NP_002604.1). | |
100 μL | |
Primary | |
Human | |
Antibody | |
Liquid |
ELISA, Western Blot | |
3P2U4 | |
Unconjugated | |
Pdpk1 | |
3-phosphoinositide dependent protein kinase 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; HGNC:8809; hPDK1; isoenzyme 1; kinase isoenzyme 1; lipoamide; mPDK1; OTTHUMP00000174525; OTTHUMP00000205076; PDK1; PDPK1; PDPK2; PDPK2P; Pkb kinase; PkB kinase like gene 1; PkB-like 1; PRO0461; Protein kinase B kinase | |
Rabbit | |
Affinity chromatography | |
RUO | |
5170 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid | |
IgG |
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