Phospho-PDPK1 (Ser241) Recombinant Rabbit Monoclonal Antibody (PDK1S241-F7), FITC, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA537339	Invitrogen™ MA537339	10 Tests
PIMA537090	Invitrogen™ MA537090	100 Tests

Description

PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.

Specifications

• Antigen: Phospho-PDPK1 (Ser241)
• Applications: Flow Cytometry
• Conjugate: FITC
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: O15530
• Gene ID (Entrez): 5170
• Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser241 of human phospho PDPK1.
• Primary or Secondary: Primary
• Content And Storage: 4°C, store in dark
• Gene: Pdpk1

• Clone: PDK1S241-F7
• Classification: Recombinant Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 0.20% BSA and 0.09% sodium azide
• Gene Alias: 3-phosphoinositide dependent protein kinase 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; HGNC:8809; hPDK1; isoenzyme 1; kinase isoenzyme 1; lipoamide; mPDK1; OTTHUMP00000174525; OTTHUMP00000205076; PDK1; PDPK1; PDPK2; PDPK2P; Pkb kinase; PkB kinase like gene 1; PkB-like 1; PRO0461; Protein kinase B kinase
• Gene Symbols: Pdpk1
• Isotype: IgG κ
• Purification Method: Protein A/G
• Product Type: Antibody