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Invitrogen™ Phospho-PERK (Thr980) Monoclonal Antibody (G.305.4)

Rabbit Monoclonal Antibody

Supplier:  Invitrogen™ MA515033

Catalog No. PIMA515033


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Description

Description

It is not recommended to aliquot this antibody.

EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.
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Specifications

Specifications

Phospho-PERK (Thr980)
Monoclonal
441 μg/mL
0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
Q9Z1Z1
EIF2AK3
Synthetic phosphopeptide corresponding to residues surrounding pThr980 of mouse PERK.
100 μL
Primary
Rat
Antibody
IgG
Western Blot
G.305.4
Unconjugated
EIF2AK3
2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS
Rabbit
Affinity chromatography
RUO
29702
-20°C
Liquid
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