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Invitrogen™ Phospho-PERK (Thr980) Monoclonal Antibody (G.305.4)
Rabbit Monoclonal Antibody
Supplier: Invitrogen™ MA515033
Description
It is not recommended to aliquot this antibody.
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.
Specifications
Phospho-PERK (Thr980) | |
Monoclonal | |
441 μg/mL | |
0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5 | |
Q9Z1Z1 | |
EIF2AK3 | |
Synthetic phosphopeptide corresponding to residues surrounding pThr980 of mouse PERK. | |
100 μL | |
Primary | |
Rat | |
Antibody | |
IgG |
Western Blot | |
G.305.4 | |
Unconjugated | |
EIF2AK3 | |
2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS | |
Rabbit | |
Affinity chromatography | |
RUO | |
29702 | |
-20°C | |
Liquid |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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