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Invitrogen™ Phospho-PERK (Thr980) Monoclonal Antibody (G.305.4)
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Catalog No. PIMA515033
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100 μL
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PIMA515033 100 μL
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Catalog No. PIMA515033 Supplier Invitrogen™ Supplier No. MA515033
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Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody.

EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PERK (Thr980)
Applications Western Blot
Classification Monoclonal
Clone G.305.4
Concentration 441 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 50% glycerol, 0.15M NaCl, 100μg/mL BSA and <0.02% sodium azide; pH 7.5
Gene EIF2AK3
Gene Accession No. Q9Z1Z1
Gene Alias 2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS
Gene Symbols EIF2AK3
Host Species Rabbit
Immunogen Synthetic phosphopeptide corresponding to residues surrounding pThr980 of mouse PERK.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29702
Target Species Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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