Invitrogen™ Phospho-PERK (Thr981) Monoclonal Antibody (4A3A10)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA550284

Catalog No. FEMA550284

Description

Phospho-PERK (Thr981) Monoclonal Antibody for ICC/IF, ELISA

EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.

Specifications

• Antigen: Phospho-PERK (Thr981)
• Classification: Monoclonal
• Concentration: 1.205 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% Proclin 300; pH 7.4
• Gene Accession No.: Q9NZJ5
• Gene Symbols: EIF2AK3
• Immunogen: Recombinant Human Eukaryotic translation initiation factor 2-alpha kinase 3 protein (115-330AA).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Immunocytochemistry
• Clone: 4A3A10
• Conjugate: Unconjugated
• Gene: EIF2AK3
• Gene Alias: 2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 9451
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid