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Invitrogen™ Phospho-PERK (Thr981) Monoclonal Antibody (4A3A10)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA550284
Description
Phospho-PERK (Thr981) Monoclonal Antibody for ICC/IF, ELISA
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.
Specifications
Phospho-PERK (Thr981) | |
Monoclonal | |
1.205 mg/mL | |
PBS with 50% glycerol and 0.03% Proclin 300; pH 7.4 | |
Q9NZJ5 | |
EIF2AK3 | |
Recombinant Human Eukaryotic translation initiation factor 2-alpha kinase 3 protein (115-330AA). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |
ELISA, Immunocytochemistry | |
4A3A10 | |
Unconjugated | |
EIF2AK3 | |
2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS | |
Mouse | |
Protein G | |
RUO | |
9451 | |
-20°C or -80°C if preferred | |
Liquid |
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