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Invitrogen™ Phospho-PINK1 (Thr313) Polyclonal Antibody
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Catalog No. PIPA5105229
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100 μL
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PIPA5105229 100 μL
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Catalog No. PIPA5105229 Supplier Invitrogen™ Supplier No. PA5105229
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of PINK1 only when phosphorylated at T313.

PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects. Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson's disease are triggered.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PINK1 (Thr313)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PINK1
Gene Accession No. Q99MQ3, Q9BXM7
Gene Alias 1190006F07Rik; AU042772; AW557854; BRPK; FLJ27236; mFLJ00387; PARK6; PINK 1; Pink1; PINK-1; protein kinase BRPK; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial
Gene Symbols PINK1
Host Species Rabbit
Immunogen A synthesized peptide derived from human PINK1(Accession Q9BXM7), corresponding to amino acid residues around phosphorylated Thr313.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 65018, 68943
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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