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Invitrogen™ Phospho-PKC alpha/beta-2 (Thr638, Thr641) Polyclonal Antibody
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Catalog No. PIPA5121268
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100 μL
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PIPA5121268 100 μL
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Catalog No. PIPA5121268 Supplier Invitrogen™ Supplier No. PA5121268
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Description

Rabbit Polyclonal Antibody

Positive test controls include: NIH/3T3. The target is usually found in the following locations: Cytoplasm, Membrane, Nucleus, Peripheral membrane protein. Immunogen sequence: VLTPP.

Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.
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Specifications

Antigen Phospho-PKC alpha/beta-2 (Thr638, Thr641)
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.44 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PRKCB
Gene Accession No. P05696, P05771, P17252, P20444, P68403, P68404
Gene Alias A130082F03Rik; AAG6; aging-associated gene 6; AI875142; PKCA; PKC-A; PKC-alpha; Pkcb; PKC-B; PKC-beta; PRKACA; PRKC Pan; PRKCA; PRKCB; PRKCB1; Prkcb2; protein kinase C alpha; protein kinase C alpha type; protein kinase C beta; protein kinase C beta I; protein kinase C beta II; protein kinase C beta type; protein kinase C beta-II; protein kinase C, alpha; protein kinase C, beta; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide; protein kinase c-alpha
Gene Symbols Prkca, PRKCB
Host Species Rabbit
Immunogen Synthetic peptide.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18750, 18751, 24680, 25023, 5578, 5579
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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