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  6. Invitrogen™ Phospho-PKC gamma (Thr514) Recombinant Rabbit Monoclonal Antibody (PKCgT514-PF4), Invitrogen™

Invitrogen™ Phospho-PKC gamma (Thr514) Recombinant Rabbit Monoclonal Antibody (PKCgT514-PF4), Invitrogen™

Catalog No. PIMA537440
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200 μL
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PIMA537440 20 μL
PIMA537192 200 μL
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Catalog No. PIMA537440 Supplier Invitrogen™ Supplier No. MA537440
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Description

Rabbit Recombinant Monoclonal Antibody

The PKC family of serine/threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC gamma is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PKC gamma (Thr514)
Applications Flow Cytometry, Western Blot
Classification Recombinant Monoclonal
Clone PKCgT514-PF4
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.10% BSA, 50% glycerol and 0.02% sodium azide
Gene PRKCG
Gene Accession No. P05129, P63318, P63319
Gene Alias PKC; Pkcc; PKCG; PKCgamma; PKC-gamma; PKCI; Prkc; Prkcc; PRKCG; protein kinase C gamma; protein kinase C gamma type; protein kinase C type I (gamma type); protein kinase C, gamma; RATPKCI; SCA14
Gene Symbols PRKCG
Host Species Rabbit
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Thr514 of human phospho PKC gamma.
Purification Method Protein A/G
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18752, 24681, 5582
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG κ
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