Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. Invitrogen™ Phospho-PKC gamma (Thr514) Recombinant Rabbit Monoclonal Antibody (PKCgT514-PF4), PE, Invitrogen™

Invitrogen™ Phospho-PKC gamma (Thr514) Recombinant Rabbit Monoclonal Antibody (PKCgT514-PF4), PE, Invitrogen™

Catalog No. PIMA537441
Change view
Click to view available options
Quantity:
10 Tests
100 Tests
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIMA537441 10 Tests
PIMA537193 100 Tests
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
Catalog No. PIMA537441 Supplier Invitrogen™ Supplier No. MA537441
Only null left
Add to Cart
Add to Cart

Description

Rabbit Recombinant Monoclonal Antibody

The PKC family of serine/threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC gamma is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PKC gamma (Thr514)
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone PKCgT514-PF4
Conjugate PE
Formulation PBS with 0.20% BSA and 0.09% sodium azide
Gene PRKCG
Gene Accession No. P05129, P63318, P63319
Gene Alias PKC; Pkcc; PKCG; PKCgamma; PKC-gamma; PKCI; Prkc; Prkcc; PRKCG; protein kinase C gamma; protein kinase C gamma type; protein kinase C type I (gamma type); protein kinase C, gamma; RATPKCI; SCA14
Gene Symbols PRKCG
Host Species Rabbit
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Thr514 of human phospho PKC gamma.
Purification Method Protein A/G
Quantity 10 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18752, 24681, 5582
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG κ
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.