Invitrogen™ Phospho-PKC zeta (Thr410) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104967

Catalog No. PIPA5104967

Description

Antibody detects endogenous levels of PKC zeta only when phosphorylated at Threonine 410.

The PKC family of serine/threonine kinases, including PRKCZ (PKC zeta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. PKC zeta plays a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function.

Specifications

• Antigen: Phospho-PKC zeta (Thr410)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRKCZ
• Gene Alias: 14 - 3 - 3 - zeta isoform; 14-3-3-zetaisoform; AI098070; aPKCzeta; atypical protein kinase C; C80388; kinase nPKC-zeta; KPCZ; nPKC-zeta; nPKC-zeta PRKCZ; PKC2; Pkcz; PKC-ZETA; Prkcz; protein kinase C zeta; protein kinase C zeta subspecies; protein kinase C zeta type; protein kinase C, zeta; r14-3-3; R74924; zetaPKC
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18762, 25522, 5590
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P09217, Q02956, Q05513
• Gene Symbols: PRKCZ
• Immunogen: A synthesized peptide derived from human PRKCZ(Accession Q05513), corresponding to amino acid residues around phosphorylated Thr410.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov