Invitrogen™ Phospho-PLA2G4A (Ser505) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA517790

Catalog No. PIPA517790

Description

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with the secreted PLA2 (sPLA2) or cytosolic Ca2+ independent PLA2 (iPLA2).

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.

Specifications

• Antigen: Phospho-PLA2G4A (Ser505)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PLA2G4A
• Gene Alias: calcium-dependent phospholipid-binding protein; Cpla2; cPLA2alpha; cPLA2-alpha; cytosolic group IVA; Cytosolic phospholipase A2; group IVA; lysophospholipase; MGC126350; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2; phospholipase A2 cytosolic; phospholipase A2 group IVA; phospholipase A2, group IVA (cytosolic, calcium-dependent); Pla2c; Pla2g4; PLA2G4A
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18783, 24653, 5321
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot
• Concentration: 250 μg/mL
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene Accession No.: P47712, P47713, P50393
• Gene Symbols: PLA2G4A
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding pSer505 of human cPLA2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Monkey
• Product Type: Antibody
• Isotype: IgG