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Invitrogen™ Phospho-PLD2 (Tyr511) Polyclonal Antibody
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Catalog No. PIPA5105377
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100 μL
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PIPA5105377 100 μL
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Catalog No. PIPA5105377 Supplier Invitrogen™ Supplier No. PA5105377
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of PLD2 only when phosphorylated at Tyr511.

PLD2 is a peripheral membrane protein belonging to phospholipase D family with a PH domain, two PLD phosphodiesterase domains and a PX (phox homology) domain that plays a regulatory rather than catalytic role. PLD2 catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid and choline. PLD2 may function in regulated secretion, signal-induced cytoskeletal regulation and/or endocytosis, transcriptional regulation, and cell cycle control. It is usually stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and activated by the ADP-ribosylation factor-1 (ARF-1). PLD2 is activated by agonist stimulation of both tyrosine kinase and G protein-coupled receptors and is also known to interact with EGFR and PIP5K1A. PLD2, localized to plasma membrane caveolae, is ubiquitously expressed in most tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PLD2 (Tyr511)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Pld2
Gene Accession No. O14939, P70498, P97813
Gene Alias choline phosphatase 2; hPLD2; phosphatidylcholine-hydrolyzing phospholipase D2; phospholipase D gene 2; phospholipase D2; PLD 2; PLD1C; PLD2; Pldc; rPLD2
Gene Symbols Pld2
Host Species Rabbit
Immunogen A synthesized peptide derived from human PLD2(Accession O14939), corresponding to amino acid residues around phosphorylated Tyr511.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18806, 25097, 5338
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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