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Invitrogen™ Phospho-PRAK (Thr182) Polyclonal Antibody
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Catalog No. PIPA599147
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100 μL
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PIPA599147 100 μL
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Catalog No. PIPA599147 Supplier Invitrogen™ Supplier No. PA599147
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of MAPKAPK5 only when phosphorylated at Threonine 182.

MAPKAPK5 (PRAK) is activated in response to cellular stress and pro-inflammatory cytokines. Activity of this kinase is regulated by p38 alpha and p38 beta. The protein encoded by PRAK is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of PRAK encoding distinct isoforms have been reported.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PRAK (Thr182)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene MAPKAPK5
Gene Accession No. O54992, Q8IW41
Gene Alias MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; Mapkapk5; MAPKAP-K5; MAPKAPK-5; mitogen-activated protein kinase-activated protein kinase 5; MK5; MK-5; p38-regulated/activated protein kinase; PRAK
Gene Symbols MAPKAPK5
Host Species Rabbit
Immunogen A synthesized peptide derived from human MAPKAPK5(Accession Q8IW41), corresponding to amino acid residues around phosphorylated Thr182.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17165, 498183, 8550
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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