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Invitrogen™ Phospho-PRAS40 (Ser202) Polyclonal Antibody
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Catalog No. PIPA5105686
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100 μL
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PIPA5105686 100 μL
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Catalog No. PIPA5105686 Supplier Invitrogen™ Supplier No. PA5105686
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of PRAS40 only when phosphorylated at Ser202.

The Akt signaling pathway contributes to the regulation of apoptosis after a variety of cell death signals. AKT1S1, also known as PRAS40, is a proline-rich substrate of the kinase AKT1 and is thought to play a role in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia. AKT1S1 is also a substrate and potential regulator of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Treatment with the insulin-like growth factor-1 (IGF1) can induce the phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PRAS40 (Ser202)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene AKT1S1
Gene Accession No. Q96B36, Q9D1F4
Gene Alias 1110012J22Rik; 40 kDa proline-rich AKT substrate; AI227026; AKT1 substrate 1; AKT1 substrate 1 (proline rich); AKT1 substrate 1 (proline-rich); akt1s1; Lobe; Lobel; OTTHUMP00000196756; OTTHUMP00000196760; PKB/Akt substrate 40; Pras; PRAS40; Proline-rich AKT substrate; proline-rich AKT1 substrate 1
Gene Symbols AKT1S1
Host Species Rabbit
Immunogen A synthesized peptide derived from human AKT1S1(Accession Q96B36), corresponding to amino acid residues around phosphorylated Ser202.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 292887, 67605, 84335
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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