Phospho-PRKD1 (Tyr463) Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS5563R

Catalog No. 50-198-6651

Description

PKD1 gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.

Specifications

• Antigen: Phospho-PRKD1 (Tyr463)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PKD1
• Gene Alias: Autosomal dominant polycystic kidney disease 1 protein; Autosomal dominant polycystic kidney disease 1 protein homolog; mFLJ00285; PBP; PC1; Pc-1; Pkd1; polycystic kidney disease 1 (autosomal dominant); polycystic kidney disease 1 homolog; polycystic kidney disease 1 homolog; polycystin-1; polycystic kidney disease-associated protein; polycystin 1; polycystin 1, transient receptor potential channel interacting; Polycystin-1; transient receptor potential cation channel, subfamily P, member 1; TRPP1
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 5310
• Content And Storage: -20°C
• Form: Liquid

• Applications: ELISA, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: P98161
• Gene Symbols: PKD1
• Immunogen: KLH conjugated synthetic phosphopeptide derived from human PRKD1 around the phosphorylation site of Tyr463.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG