Invitrogen™ Phospho-PTPN3 (Ser459) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA535413

Catalog No. PIPA535413

Description

This antibody is predicted to react with bovine, canine, non-human primate and sheep based on 100% sequence homology. This antibody contains enough material to conduct 10 mini-Western blots.

Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation - it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.

Specifications

• Antigen: Phospho-PTPN3 (Ser459)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PTPN3
• Gene Alias: 9530011I20Rik; cytoskeletal-associated protein tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 3; protein-tyrosine phosphatase H1; PTPCL; PTPH1; PTP-H1; Ptpn3; Tyrosine-protein phosphatase non-receptor type 3
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 545622, 5774
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.25 mg/mL
• Formulation: 0.01M HEPES with 0.1mg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene Accession No.: A2ALK8, P26045
• Gene Symbols: PTPN3
• Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser459 of human PTPH1 conjugated to KLH.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov