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Invitrogen™ Phospho-PTRF (Tyr156) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599575

Catalog No. PIPA599575


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Description

Description

Antibody detects endogenous levels of PTRF only when phosphorylated at Tyr156.

The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts. PTRF also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation. PTRF is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-PTRF (Tyr156)
Polyclonal
Unconjugated
CAVIN1
2310075E07Rik; AW546441; caveolae associated protein 1; caveolae-associated protein 1; CAVIN; CAVIN1; cavin-1; Cav-p60; CGL4; FKSG13; FLJ90031; Polymerase I and transcript release factor; PTRF; ptrf {ECO:0000312; RGD:1307685}; RNA polymerase I and transcript release factor; TTF-I interacting peptide 12
Rabbit
Sequential Chromatography
RUO
19285, 284119, 287710
-20°C
Liquid
Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
O54724, P85125, Q6NZI2
CAVIN1
A synthesized peptide derived from human CAVIN1(Accession Q6NZI2), corresponding to amino acid residues around phosphorylated Tyr156.
100 μL
Primary
Human, Mouse, Rat, Monkey
Antibody
IgG
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