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Invitrogen™ Phospho-PYK2 (Tyr579) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA537573

Catalog No. PIPA537573


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Description

Description

A suggested positive control for Western blot is NIH-3T3 or HepG2 cells; suggested positive control for IHC is human brain tissue.

PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-PYK2 (Tyr579)
Polyclonal
Unconjugated
PTK2B
CADTK; CAK beta; CAKB; CAKbeta; CAK-beta; calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; cellular adhesion kinase beta; E430023O05Rik; FADK; FADK 2; FADK2; FAK; FAK1; FAK2; focal adhesion kinase 2; FRNK; PKB; pp125FAK; proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; PTK; PTK2 protein tyrosine kinase 2 beta; PTK2B; PTK2B protein tyrosine kinase 2 beta; PYK2; RAFTK; related adhesion focal tyrosine kinase
Rabbit
Affinity chromatography
RUO
19229, 2185
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q14289, Q9QVP9
PTK2B
Peptide sequence around phosphorylation site of tyrosine 579(E-D-Y(p)-Y-K) derived from Human PYK2.
100 μL
Primary
Human, Mouse
Antibody
IgG
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