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Invitrogen™ Phospho-RAD17 (Ser359) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5105434

Catalog No. PIPA5105434


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Description

Description

Antibody detects endogenous levels of RAD17 only when phosphorylated at Ser359.

Rad17 is essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. It has a weak ATPase activity required for binding to chromatin. Rad17 also participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-RAD17 (Ser359)
Polyclonal
Unconjugated
Rad17
CCYC; cell cycle checkpoint protein (RAD17); cell cycle checkpoint protein RAD17; DNA damage checkpoint control protein RAD17; DNA repair exonuclease RAD17; FLJ41520; hRad17; MmRad24; R24L; RAD1 homolog; RAD17; RAD17 (Ser647); RAD17 checkpoint clamp loader component; RAD17 homolog; RAD17 homolog (S. pombe); Rad17 like protein; Rad17-like protein; Rad17p; RAD17SP; RAD24; RF-C activator 1 homolog; RF-C/activator 1 homolog; YOR368W
Rabbit
Sequential Chromatography
RUO
19356, 310034, 5884
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
O75943, Q6NXW6
Rad17
A synthesized peptide derived from human RAD17(Accession O75943), corresponding to amino acid residues around phosphorylated Ser359.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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