Invitrogen™ Phospho-RSK Pan (Ser221, Ser227, Ser218, Ser232) Recombinant Superclonal™ Antibody

Rabbit Recombinant Superclonal Antibody

Supplier:  Invitrogen™ 711336

Catalog No. PI711336

Description

This antibody is predicted to react with Monkey, Rat and Mouse Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called Recombinant polyclonal antibody, this product is now rebranded as Recombinant Superclonal™ antibody. The physical product and the performance remain unchanged.

The p90 ribosomal S6 kinases (RSKs) comprise a family of serine/threonine kinases that lie at the terminus of the ERK pathway. In humans, the RSK family consists of four isoforms (RSK1 to-4). RSK family members are unusual among serine/threonine kinases in that they contain two distinct kinase domains, both of which are catalytically functional. Theses kinase domains are activated in a sequential manner by a series of phosphorylations. RSK regulates gene expression via association and phosphorylation of transcriptional regulators including c-Fos, estrogen receptor, NFkappaB/IkappaB alpha, cAMP-response element-binding protein (CREB). ERK activates the C-terminal kinase of RSK, leading to activation of the N-terminal kinase. Members of the RSK family are present in the cytoplasm as well as the nucleus. Addition of growth factor to the cells results in the activation of both cytosolic and nuclear RSK and the translocation of the cytosolic RSK into the nucleus upon activation. The activation and nuclear translocation of RSK result in phosphorylation and activation of transcription factors.

Specifications

• Antigen: Phospho-RSK Pan (Ser221, Ser227, Ser218, Ser232)
• Classification: Recombinant Superclonal
• Conjugate: Unconjugated
• Gene: RPS6KA1
• Gene Alias: 1110069D02Rik; 2610524K04Rik; 90 kDa ribosomal protein S6 kinase 1; 90 kDa ribosomal protein S6 kinase 2; 90 kDa ribosomal protein S6 kinase 3; 90 kDa ribosomal protein S6 kinase 4; 90 kDa ribosomal protein S6 kinase 6; 90kDa; AI848992; C130006E23; CLS; D17Wsu134e; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); HU-1; HU-2; HU-3; Insulin-stimulated protein kinase 1; ISPK1; ISPK-1; MAP kinase-activated protein kinase 1a; MAP kinase-activated protein kinase 1b; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1a; MAPK-activated protein kinase 1b; MAPK-activated protein kinase 1c; MAPKAP kinase 1a; MAPKAP kinase 1b; MAPKAP kinase 1c; MAPKAPK1A; MAPKAPK-1a; MAPKAPK1B; MAPKAPK-1b; MAPKAPK1C; MAPKAPK-1c; MAPKAPK1D; mitogen- and stress-activated protein kinase 2; mitogen- and stress-activated protein kinase-2; mitogen-activated protein kinase-activated protein kinase 1C; mMSK2; MPK-9; MRX19; Msk2; Nuclear mitogen- and stress-activated protein kinase 2; p90 rsk; p90rsk; p90-RSK 1; p90-RSK 2; p90-RSK 3; p90-RSK 6; p90RSK1; p90-Rsk1; p90RSK2; p90-RSK2; p90RSK3; p90-RSK3; p90RSK6; p90S6K; pp90rsk; pp90RSK2; pp90RSK3; PP90RSK4; Protein-tyrosine kinase Mpk-9; ribosomal protein kinase B; ribosomal protein S6 kinase 2; ribosomal protein S6 kinase A1; ribosomal protein S6 kinase A2; ribosomal protein S6 kinase A3; ribosomal protein S6 kinase A4; ribosomal protein S6 kinase A6; ribosomal protein S6 kinase alpha 1; ribosomal protein S6 kinase alpha 2; ribosomal protein S6 kinase alpha 4; ribosomal protein S6 kinase alpha-1; Ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase alpha-3; Ribosomal protein S6 kinase alpha-4; ribosomal protein S6 kinase alpha-6; ribosomal protein S6 kinase polypeptide 1; ribosomal protein S6 kinase polypeptide 3; ribosomal protein S6 kinase polypeptide 6; ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1; ribosomal protein S6 kinase, 90kD, polypeptide 2; ribosomal protein S6 kinase, 90kD, polypeptide 4; ribosomal protein S6 kinase, 90kDa, polypeptide 1; ribosomal protein S6 kinase, 90kDa, polypeptide 2; ribosomal protein S6 kinase, 90kDa, polypeptide 3; ribosomal protein S6 kinase, 90kDa, polypeptide 4; ribosomal protein S6 kinase, 90kDa, polypeptide 6; ribosomal protein S6 kinase, polypeptide 2; ribosomal protein S6 kinase, polypeptide 4; ribosomal S6 kinase 1; Ribosomal S6 kinase 2; ribosomal S6 kinase 3; Ribosomal S6 kinase 4; RLSK; RP11-393H10.3; Rps6ka1; RPS6KA2; Rps6ka3; RPS6KA4; RPS6KA6; Rps6ka-rs1; RSK; Rsk1; RSK-1; Rsk2; RSK-2; Rsk3; RSK-3; RSK4; RSK-4; RSKB; RSK-B; RSK-like protein kinase; S6K-alpha; S6K-alpha 1; S6K-alpha 2; S6K-alpha 6; S6K-alpha-1; S6K-alpha2; S6K-alpha-2; S6K-alpha3; S6K-alpha-3; S6K-alpha-4; S6K-alpha-6
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 27330, 6195, 6196, 6197, 8986
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: O75676, P51812, Q15349, Q15418, Q9UK32
• Gene Symbols: RPS6KA1, RPS6KA2, Rps6ka3, RPS6KA4, RPS6KA6
• Immunogen: A synthesized peptide derived from human RSK1/2/3/4 around the phosphorylation site of Ser221/227/218/223.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov