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Invitrogen™ Phospho-RyR3 (Ser160) Polyclonal Antibody
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Catalog No. PIPA5104559
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100 μL
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PIPA5104559 100 μL
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Catalog No. PIPA5104559 Supplier Invitrogen™ Supplier No. PA5104559
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of RYR3 only when phosphorylated at Ser160.

RYR3 is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. RYR3 is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms of RYR3 have been found. RYR3 mediates calcium channel release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and plays a role in triggering muscle contraction. Further, RYR3 may also regulate Ca(2+) release by other calcium channels, as well as Ca(2+) release from the endoplasmic reticulum in non-muscle cells. RYR3 also contributes to cellular calcium ion homeostasis. Plays a role in cellular calcium signaling. Diseases associated with RYR3 include Central Core Disease and Arrhythmogenic Right Ventricular Dysplasia 2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-RyR3 (Ser160)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene RYR3
Gene Accession No. A2AGL3, Q15413
Gene Alias AI851294; Brain ryanodine receptor-calcium release channel; brain-type ryanodine receptor; C230090H21; calcium release channel; HBRR; Ryanodine receptor 3; RYR3; RYR-3; Type 3 ryanodine receptor
Gene Symbols RYR3
Host Species Rabbit
Immunogen A synthesized peptide derived from human RYR3(Accession Q15413), corresponding to amino acid residues around phosphorylated Ser160.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20192, 6263
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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