Phospho-Separase (Ser1126) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA512691

Catalog No. PIPA512691

Description

The metaphase-to-anaphase transition is the final discrete event in duplication and separation of the genetic material of the cell. Its timing is regulated by the activation of the anaphase-promoting complex (APC). In both budding and fission yeast, the degradation of the Pds1 or Cut2 protein, respectively, is required for the onset of sister chromatid separation. Both proteins are APC substrates. Pds1 and Cut2 proteins associate with the yeast separin proteins Esp1 and Cut1, respectively, and prevent the separins from promoting chromatid separation. Pds1 and Cut2 are also called anaphase inhibitors or securins

Specifications

• Antigen: Phospho-Separase (Ser1126)
• Classification: Polyclonal
• Gene: ESPL1
• Gene Alias: Separin; Separase; Caspase-like protein ESPL1; Extra spindle poles-like 1 protein; ESPL1; ESP1; KIAA0165;
• Host Species: Rabbit
• Purification Method: Protein A, Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9700
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Dot Blot, Immunohistochemistry
• Conjugate: Unconjugated
• Gene Accession No.: Q14674
• Gene Symbols: ESPL1
• Immunogen: KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1126 of human SEPARIN
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG