Phospho-Separase (Ser801) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA538245

Catalog No. PIPA538245

Description

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 or STAG2 in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 by ESPL1, or separase, which initiates the final separation of sister chromatids .

Specifications

• Antigen: Phospho-Separase (Ser801)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ESPL1
• Gene Alias: ESP1, FLJ46492, KIAA0165, caspase-like protein ESPL1, extra spindle poles like 1, extra spindle poles-like 1 protein, separin
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 105988, 9700
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q14674, P60330
• Gene Symbols: ESPL1
• Immunogen: A synthetic phosphopeptide derived from human SEPARASE around the phosphorylation site of Ser801 (N-S-SP-P-V)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG