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Invitrogen™ Phospho-(Ser/Thr) ATM + ATR Substrate Polyclonal Antibody
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Catalog No. PIPA5117231
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100 μL
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PIPA5117231 100 μL
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Catalog No. PIPA5117231 Supplier Invitrogen™ Supplier No. PA5117231
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Description

Rabbit Polyclonal Antibody

Positive Samples: Jurkat, NIH/3T3, C6.

Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are related kinases that regulate cell cycle checkpoints and DNA repair. The identified substrates for ATM are p53, p95/NBS1, MDM2, Chk2, BRCA1, CtIP, 4E-BP1, and Chk1. The essential requirement for the substrates of ATM/ATR is S*/T*Q. Hydrophobic amino acids at positions -3 and -1, and negatively charged amino acids at position +1 are positive determinants for substrate recognition by these kinases. Positively charged residues surrounding the S*/T*Q are negative determinants for substrate phosphorylation. The complex phenotype of AT cells suggests that it likely has additional substrates.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-(Ser/Thr) ATM + ATR Substrate
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.65 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Alias L(s/t)Q; SQ/TQ
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence containing phosphorylated S & T.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species All species
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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