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Invitrogen™ Phospho-SF3B1 (Thr211) Polyclonal Antibody
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Catalog No. PIPA5105427
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PIPA5105427 100 μL
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Catalog No. PIPA5105427 Supplier Invitrogen™ Supplier No. PA5105427
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of SF3B1 only when phosphorylated at Thr211.

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex. The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-SF3B1 (Thr211)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SF3B1
Gene Accession No. O75533, Q99NB9
Gene Alias 155kDa; 2810001M05Rik; AA409119; Hsh155; LOW QUALITY PROTEIN: splicing factor 3B subunit 1; MDS; pre-mRNA processing 10; pre-mRNA splicing factor SF3b, 155 kDa subunit; pre-mRNA-splicing factor SF3b 155 kDa subunit; PRP10; PRPF10; SAP 155; SAP155; SF3B1; SF3b155; spliceosome-associated protein 155; Splicing factor 3B subunit 1; splicing factor 3b subunit 1, 155kDa; splicing factor 3b, subunit 1; splicing factor 3b, subunit 1, 155 kDa; splicing factor 3b, subunit 1, 155kD; splicing factor 3b, subunit 1, 155kDa; TA-8; Targ4; transforming growth factor alpha regulated gene 4; tst; wu:fb99f09
Gene Symbols SF3B1
Host Species Rabbit
Immunogen A synthesized peptide derived from human SF3B1(Accession O75533), corresponding to amino acid residues around phosphorylated Thr211.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23451, 81898, 84486
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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