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  6. Invitrogen™ Phospho-SHP-1 (Tyr536) Recombinant Rabbit Monoclonal Antibody (Shp1Y536-2A7), PE, Invitrogen™

Invitrogen™ Phospho-SHP-1 (Tyr536) Recombinant Rabbit Monoclonal Antibody (Shp1Y536-2A7), PE, Invitrogen™

Catalog No. PIMA537375
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PIMA537129 100 Tests
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Catalog No. PIMA537375 Supplier Invitrogen™ Supplier No. MA537375
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Description

Rabbit Recombinant Monoclonal Antibody

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-SHP-1 (Tyr536)
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone Shp1Y536-2A7
Conjugate PE
Formulation PBS with 0.20% BSA and 0.09% sodium azide
Gene PTPN6
Gene Accession No. P29350
Gene Alias 70Z-SHP; EC 3.1.3.48; hcp; Hcph; hematopoietic cell phosphatase; hematopoietic cell protein-tyrosine phosphatase; HPTP1C; me; motheaten; protein tyrosine phosphatase, non-receptor type 6; protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; Ptp1C; PTP-1C; Ptph6; PTPN6; PTPTY-42; SH2 phosphatase 1; SHP1; Shp-1; SHP-1L; SH-PTP1; Tyrosine-protein phosphatase non-receptor type 6
Gene Symbols PTPN6
Host Species Rabbit
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Tyr536 of human phospho Shp1.
Purification Method Protein A/G
Quantity 10 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5777
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG κ
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