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Invitrogen™ Phospho-SHP2 (Tyr580) Polyclonal Antibody
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Catalog No. PIPA517186
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PIPA517186 100 μL
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Catalog No. PIPA517186 Supplier Invitrogen™ Supplier No. PA517186
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Description

Rabbit Polyclonal Antibody

It is not recommended to aliquot this antibody.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-SHP2 (Tyr580)
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 22 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 50% glycerol, 100μg/mL BSA, 0.15M NaCl and no preservative; pH 7.5
Gene PTPN11
Gene Accession No. P35235, P41499, Q06124
Gene Alias 2700084A17Rik; AW536184; bptp3; CFC; cSH-PTP2; encodes catalytic domain; HCP; HGNC:9644; JMML; METCDS; MGC14433; Noonan syndrome 1; ns1; null; OTTHUMP00000166108; phosphotyrosyl-protein phosphatase; protein tyrosine phosphatase non-receptor type 11; protein tyrosine phosphatase SH-PTP2; protein tyrosine phosphatase, non-receptor type 11; protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1); protein tyrosine phosphatase, non-receptor type 11 S homeolog; protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; protein-tyrosine phosphatase SYP; PTP1C; PTP1D; PTP-1D; ptp-2; PTP2C; PTP-2C; Ptpn11; ptpn11.S; ptpn11-a; ptpn11-b; SAP-2; SH2 domain-containing protein tyrosine phosphatase-2; Shp2; shp-2; SHPTP2; SH-PTP2; SH-PTP2 protein tyrosine phosphatase non-receptor type 11; SH-PTP2 protein tyrosine phosphatase, non-receptor type 11; SH-PTP3; Syp; Tyrosine-protein phosphatase non-receptor type 11; XELAEV_18010676mg
Gene Symbols PTPN11
Host Species Rabbit
Immunogen Synthetic phosphopeptide corresponding to residues surrounding pTyr580 of human SHP-2.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19247, 25622, 5781
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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