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Invitrogen™ Phospho-SIRT1 (Ser27) Polyclonal Antibody
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Catalog No. PIPA5105222
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100 μL
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Catalog No. Quantity
PIPA5105222 100 μL
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Catalog No. PIPA5105222 Supplier Invitrogen™ Supplier No. PA5105222
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of SirT1 only when phosphorylated at Ser27.

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-SIRT1 (Ser27)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SIRT1
Gene Accession No. Q96EB6
Gene Alias 75SirT1; AA673258; hSIR2; hSIRT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; SIR2; Sir2a; SIR2alpha; SIR2L1; sir2-like 1; SIR2-like protein 1; SIRT 1; SIRT1; SIRT-1; SirtT1 75 kDa fragment; sirtuin 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1
Gene Symbols SIRT1
Host Species Rabbit
Immunogen A synthesized peptide derived from human SIRT1(Accession Q96EB6), corresponding to amino acid residues around phosphorylated Ser27.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23411
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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