Phospho-SIRT2 (Ser331) Monoclonal Antibody (6B5), Active Motif™

Catalog No.	Quantity
50-199-3347	10 μg
50-199-3346	100 μg

Catalog No. 50-199-3347 Supplier Active Motif Supplier No. 61364

Description

Rat Monoclonal Antibody

The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.

Specifications

• Antigen: Phospho-SIRT2 (Ser331)
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 6B5
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
• Gene: SIRT2
• Gene Accession No.: Q8IXJ6
• Gene Alias: 5730427M03Rik; 5E5 antigen; mSIR2L2; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; Regulatory protein SIR2 homolog 2; silent information regulator 2; silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2; SIR2; SIR2L; SIR2L2; SIR2-like protein 2; sir2-related protein type 2; SIRT2; sirtuin 2; sirtuin type 2; sirtuin-2
• Gene Symbols: SIRT2
• Host Species: Rat
• Immunogen: This antibody was raised against a synthetic peptide corresponding to human SIRT2 phosphorylated at Serine 331.
• Purification Method: Protein G
• Quantity: 10 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 22933
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a