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Invitrogen™ Phospho-SMAD1/SMAD5/SMAD9 (Ser463, Ser465, Ser467) Recombinant Rabbit Monoclonal Antibody (RM487)
Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA562161

Description
This antibody reacts to Smad1 and Smad5 when phosphorylated at Ser463/465 and Smad9 (Smad8) when phosphorylated at Ser465/467. There is no cross-reactivity to Smad1, Smad5, or Smad9 that are not phosphorylated. This antibody reacts to human, mouse or rat Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad9 (Ser465/467).
The protein encoded by SMAD1/SMAD5/SMAD8/SMAD9 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Specifications
Phospho-SMAD1/SMAD5/SMAD9 (Ser463, Ser465, Ser467) | |
Recombinant Monoclonal | |
Conc. Not Determined | |
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide | |
O15198, Q15797, Q99717 | |
SMAD1, Smad5, SMAD9 | |
Protein A | |
RUO | |
4086, 4090, 4093 | |
-20°C | |
Liquid |
Western Blot | |
RM487 | |
Unconjugated | |
SMAD9 | |
1110051M15Rik; AI451355; AI528653; BSP1; BSP-1; dwarfin-A; Dwarfin-C; dwf-A; DWFC; Dwf-C; JV41; JV4-1; JV5-1; MAD (mothers against decapentaplegic, Drosophila) homolog 1; MAD homolog 1; MAD homolog 5; MAD homolog 9; MAD homolog1 (mothers against decapentaplegic, Drosophila); MAD, mothers against decapentaplegic homolog 1; MAD, mothers against decapentaplegic homolog 5; MADH1; MADH5; MADH6; Madh8; Madh9; Madr1; mad-related protein 1; Mlp1; mMad1; mothers against decapentaplegic homolog 1; Mothers against decapentaplegic homolog 5; mothers against decapentaplegic homolog 9; mothers against decapentaplegic, drosophila, homolog of, 5; Mothers against decapentaplegic, drosophila, homolog of, 9; mothers against DPP homolog 1; mothers against DPP homolog 5; mothers against DPP homolog 9; mothers-against-DPP-related 1; Msmad5; MusMLP; PPH2; SMA- and MAD-related protein 5; SMAD; Smad 1; SMAD 5; SMAD 9; SMAD family member 1; SMAD family member 5; SMAD family member 9; SMAD, mothers against DPP homolog 1; SMAD, mothers against DPP homolog 5; SMAD, mothers against DPP homolog 9; SMAD1; Smad5; Smad8; SMAD8/9; SMAD8A; SMAD8B; Smad9; TGF-beta signaling protein 1; transforming growth factor-beta signaling protein 1; Transforming growth factor-beta-signaling protein 1 | |
A phospho-peptide corresponding to human Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad9 (Ser465/467). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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