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Invitrogen™ Phospho-SMO (Ser616) Polyclonal Antibody
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Catalog No. PIPA5121319
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100 μL
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PIPA5121319 100 μL
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Catalog No. PIPA5121319 Supplier Invitrogen™ Supplier No. PA5121319
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Description

Rabbit Polyclonal Antibody

The target is usually found in the following locations: Cell projection, Membrane, Multi-pass membrane protein, cilium. Immunogen sequence: VSSAW.

Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-SMO (Ser616)
Applications Dot Blot, ELISA, Western Blot
Classification Polyclonal
Concentration 0.95 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene SMO
Gene Accession No. Q99835
Gene Alias bent body; bnb; E130215L21Rik; frizzled family member 11; FZD11; Gx; HGNC:11119; Protein Gx; Protein SMOH; seven transmembrane helix receptor; SMO; SMOH; smoothened; Smoothened homolog; smoothened homolog (Drosophila); smoothened, frizzled class receptor; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor
Gene Symbols SMO
Host Species Rabbit
Immunogen A synthetic phosphorylated peptide around S616 of human SMO (NP_005622.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6608
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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