Invitrogen™ Phospho-SNAIL (Ser246) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104712

Catalog No. PIPA5104712

Description

Antibody detects endogenous levels of SNAIL only when phosphorylated at Serine 246.

Zinc finger protein SNAI1 (SNAIL)is a zinc finger transcriptional repressor which down regulates the expression of the ectodermal gene within the mesoderm and functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stromamay be anew putative prognosis marker for colon tumors.

Specifications

• Antigen: Phospho-SNAIL (Ser246)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Snai1
• Gene Alias: AI194338; dJ710H13.1; Protein sna; protein snail homolog 1; SLUGH2; SNA; Sna protein; Sna1; SNAH; snai; SNAI1; Snail; snail 1; snail 1 homolog; snail 1 zinc finger protein; snail 1, zinc finger protein; snail family transcriptional repressor 1; snail family zinc finger 1; snail homolog 1; Snail1; Zinc finger protein SNAI1
• Host Species: Rabbit
• Purification Method: Sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116490, 20613, 6615
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O95863, Q02085
• Gene Symbols: Snai1
• Immunogen: A synthesized peptide derived from human SNAI1(Accession O95863), corresponding to amino acid residues around phosphorylated Ser246.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov