Invitrogen™ Phospho-SOX9 (Ser181) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104914

Catalog No. PIPA5104914

Description

Antibody detects endogenous levels of SOX9 only when phosphorylated at Serine 181.

SOX9 has a role in sex determination and differentiation of Sertoli cells. It is involved in chondrogenesis and regulates the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Translocation of this gene can cause campomelic dysplasia. SOX9 is involved in the formation of testes from the indifferent fetal gonads. It is a major molecular component of the neuron-glia switch in developing spinal cord. During normal development, SOX9 allows the prostate epithelium to outgrow into the mesenchyme and then provides basal cell support for development and maintenance of the luminal epithelium. These functions of SOX9 are subverted in prostate cancer to support tumor growth and invasion. SOX9 may direct the formation of neural crest precursors and the development of a range of neural crest derivative. It has a transcriptional regulation in melanin production in cells. Northern blot analysis shows its expression on adult testis, adult heart, and fetal brain.

Specifications

• Antigen: Phospho-SOX9 (Ser181)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SOX9
• Gene Alias: 2010306G03Rik; AV220920; CMD1; CMPD1; mKIAA4243; SOX 9; Sox9; SOX-9; Sox9 transcription factor; SRA1; SRXX2; SRXY10; SRY (sex determining region Y)-box 9; SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal); SRY (sex determining region Y)-box9; SRY (sex-determining region Y)-box 9 protein; SRY box 9; SRY-box 9; SRY-Box 9 ; SRY-box containing 9; SRY-box containing gene 9; SRY-box containing protein 9; SRY-box transcription factor 9; SRY-related HMG-box, gene 9; transcription activator Sox9; transcription factor SOX-9
• Host Species: Rabbit
• Purification Method: sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20682, 374148, 6662
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P48434, P48436, Q04887
• Gene Symbols: SOX9
• Immunogen: A synthesized peptide derived from human SOX9(Accession P48436), corresponding to amino acid residues around phosphorylated Ser181.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Chicken
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov