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Phospho-SP1 (Thr453) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501982220
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50-198-2220 100 μL
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Catalog No. 50-198-2220 Supplier Bioss Supplier No. BS12412R
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Description

Rabbit Polyclonal Antibody

SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.

Specifications

Antigen Phospho-SP1 (Thr453)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene SP1
Gene Accession No. P08047
Gene Alias 1110003E12Rik; AA450830; AI845540; HGNC:11205; Sp1; Sp1 transcription factor; Sp1-1; Specificity protein 1; trans-acting transcription factor 1; Transcription factor Sp1; TSFP1
Gene Symbols SP1
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human TSFP1 around the phosphorylation site of Thr453.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6667
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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