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Invitrogen™ Phospho-STAT1 (Ser727) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597355

Catalog No. PIPA597355


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Description

Description

Positive Samples: 293T, C6; Cellular Location: Cytoplasm, Nucleus Immunogen sequence: PMSPEE.

STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-STAT1 (Ser727)
Polyclonal
Unconjugated
STAT1
2010005J02Rik; AA408197; CANDF7; DD6G4-4; DKFZp686B04100; IMD31A; IMD31B; IMD31C; ISGF-3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta; OTTHUMP00000165046; OTTHUMP00000205845; signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT; STAT 1; STAT1; STAT-1; stat1 alpha; STAT91; transcription factor ISGF-3; transcription factor ISGF-3 components p91/p84
Rabbit
Affinity chromatography
RUO
20846, 25124, 6772
-20°C, Avoid Freeze/Thaw Cycles
Liquid
ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
0.42 mg/mL
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
P42224, P42225
STAT1
A synthetic phosphorylated peptide around S727 of human STAT1 (NP_0093301).
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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