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Phospho-STAT5A/B (Ser726, Ser731) Polyclonal Antibody, Active Motif™
SDP

Catalog No. 501992731
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200 μL
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50-199-2731 200 μL
50-199-2732 10 μL
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Catalog No. 50-199-2731 Supplier Active Motif Supplier No. 39597
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Description

Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

Specifications

Antigen Phospho-STAT5A/B (Ser726, Ser731)
Applications Dot Blot, Western Blot
Classification Polyclonal
Concentration Lot-Specific
Conjugate Unconjugated
Formulation 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene STAT5B
Gene Accession No. P42229, P51692
Gene Alias AA959963; Mammary gland factor; mammary gland factor STAT5A; mammary gland factor STAT5B; Mgf; Mpf; signal transducer and activator of transcription 5; Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5B; STA5B; STAT; STAT5; Stat5a; STAT5B; transcription factor STAT5B
Gene Symbols STAT5A, STAT5B
Host Species Rabbit
Immunogen This STAT5A/B phospho Ser726/Ser731 antibody was raised against a peptide containing phospho Ser726 of human STAT5A. Human STAT5B shares the identical sequence surrounding Ser731.
Purification Method Antigen affinity chromatography
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6776, 6777
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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