Invitrogen™ Phospho-STAT6 (Tyr641) Monoclonal Antibody (J.187.3)

Rabbit Monoclonal Antibody

Supplier:  Invitrogen™ MA514920

Catalog No. PIMA514920

Description

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with the corresponding phospho-tyrosine residues of other Stat proteins.

STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. (Stat6-/-) were found to be deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response. STAT6 is crucial for IL-4-mediated biological responses, and naturally in two isoforms: STAT6a and STAT6c.

Specifications

• Antigen: Phospho-STAT6 (Tyr641)
• Classification: Monoclonal
• Concentration: 103 μg/mL
• Formulation: 0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
• Gene Accession No.: P42226
• Gene Symbols: STAT6
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding pTyr641 of human Stat6.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot, Immunocytochemistry
• Clone: J.187.3
• Conjugate: Unconjugated
• Gene: STAT6
• Gene Alias: 12S1644; D12S1644; IL4 STAT; IL-4 Stat; IL-4-STAT; signal transducer and activator of transcription 6; signal transducer and activator of transcription 6, interleukin-4 induced; signal transducer and transcription activator 6; STAT; STAT, interleukin4-induced; Stat6; STAT-6; STAT6B; STAT6C; transcription factor IL-4 STAT
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6778
• Content And Storage: -20°C
• Form: Liquid