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Invitrogen™ Phospho-SYK (Tyr525) Polyclonal Antibody
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Catalog No. PIPA5104904
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Quantity:
100 μL
Catalog No. Quantity
PIPA5104904 100 μL
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Catalog No. PIPA5104904

Supplier: Invitrogen™ PA5104904

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of SYK only when phosphorylated at Tyrosine 525.

Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-SYK (Tyr525)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Syk
Gene Accession No. P43405, P48025, Q64725
Gene Alias DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; SYK; syk signaling; Sykb; tyrosine-kinase syk; tyrosine-protein kinase SYK
Gene Symbols Syk
Host Species Rabbit
Immunogen A synthesized peptide derived from human SYK(Accession P43405), corresponding to amino acid residues around phosphorylated Tyr525.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20963, 25155, 6850
Target Species Human, Mouse, Rat, Monkey
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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