Phospho-Syk (Tyr525, Tyr526) Rabbit anti-Human∣Mouse∣Rat, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS3434R

Catalog No. 50-198-5396

Description

Syk is a cytoplasmic protein tyrosine kinase that translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.

Specifications

• Antigen: Phospho-Syk (Tyr525, Tyr526)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Syk
• Gene Alias: DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; Spleen tyrosine kinase; Syk; Sykb; Tyrosine-protein kinase SYK
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 20963, 25155, 6850
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: P43405, P48025, Q64725
• Gene Symbols: Syk
• Immunogen: KLH conjugated synthetic phosphopeptide derived from human Syk around the phosphorylation site of Tyr525/526.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG