Invitrogen™ Phospho-Synaptotagmin 1 (Thr202) Polyclonal Antibody

Catalog No.	Quantity
PA14642	100 μL

Catalog No. PA14642 Supplier Invitrogen™ Supplier No. PA14642

Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with bovine, canine, chicken, human, mouse, non-human primate and zebrafish based on 100% sequence homology. This antibody is specific for the ~60 kDa to 62 kDa Synaptotagmin protein phosphorylated at Ser309 in Western blots of rat brain lysates.

Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release. Studies indicate that synaptotagmin's Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane. It has been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Synaptotagmin 1 may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Further, Synaptotagmin 1 binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has been reported. Synaptotagmin 1 can also bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Diseases associated with the dysfunction of Synaptotagmin 1 include food-borne botulism and infant botulism.

Specifications

• Antigen: Phospho-Synaptotagmin 1 (Thr202)
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.25 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene: Syt1
• Gene Accession No.: P21707
• Gene Alias: AW124717; DKFZp781D2042; FLJ42519; G630098F17Rik; P65; SV DKFZp781D2042; SV SYT; svp65; Syb1; synaptotagmin 1; synaptotagmin 1 L homeolog; synaptotagmin 2; synaptotagmin I; synaptotagmin I protein; synaptotagmin I variant b; Synaptotagmin II; Synaptotagmin XI; synaptotagmin-1; Synaptotagmin-2; SYT; Syt1; syt1.L; SYT2; SytI; SytII; XELAEV_18022019mg
• Gene Symbols: Syt1
• Host Species: Rabbit
• Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr202 of rat SYT1 conjugated to KLH.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 25716
• Target Species: Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG