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Invitrogen™ Phospho-TACC3 (Tyr560) Polyclonal Antibody
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Catalog No. PIPA5105702
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100 μL
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PIPA5105702 100 μL
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Catalog No. PIPA5105702 Supplier Invitrogen™ Supplier No. PA5105702
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of TACC3 only when phosphorylated at Tyr560.

TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors. TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 4,8, and 10. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC. It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-TACC3 (Tyr560)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TACC3
Gene Accession No. Q9JJ11, Q9Y6A5
Gene Alias Aint; Arnt interacting protein; ARNT-interacting protein; C86661; ERIC1; ERIC-1; Tacc3; transforming acidic coiled coil 3; transforming acidic coiled-coil containing protein 3; transforming acidic coiled-coil-containing protein 3; transforming, acidic coiled-coil containing protein 3
Gene Symbols TACC3
Host Species Rabbit
Immunogen A synthesized peptide derived from human TACC3(Accession Q9Y6A5), corresponding to amino acid residues around phosphorylated Tyr560.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10460, 21335, 360962
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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