Invitrogen™ Phospho-TAOK2 (Ser181) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114650

Catalog No. PIPA5114650

Description

Antibody detects endogenous levels of TAO2 only when phosphorylated at Ser181.

TAOK2 (TAO1) is a serine/threonine kinase that may be an important regulator of the stress-responsive p38 MAP kinase pathway. In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEK ) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonist to the stress -responsive p38 MAPK (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.

Specifications

• Antigen: Phospho-TAOK2 (Ser181)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TAOK2
• Gene Alias: 1110033K02Rik; B230344N16; hKFC-C; Kiaa0881; Kinase from chicken homolog C; MAP3K17; mKIAA0881; prostate derived STE20-like kinase PSK; prostate-derived STE20-like kinase 1; prostate-derived sterile 20-like kinase 1; PSK; PSK1; PSK-1; PSK1-BETA; serine/threonine protein kinase TAO2; serine/threonine-protein kinase TAO2; serine-threonine kinase; tao; TAO kinase 2; TAO kinase 2TAO kinase 2; TAO1; TAO2; TAOK2; Thousand and one amino acid protein 2; thousand and one amino acid protein kinase 2; UNQ2971/PRO7431
• Host Species: Rabbit
• Purification Method: Sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 381921, 64666, 9344
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q6ZQ29, Q9JLS3, Q9UL54
• Gene Symbols: TAOK2
• Immunogen: A synthesized peptide derived from human TAO2 around the phosphorylation site of Ser181.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG